Fluorobenzene → 2-(4-Fluorobenzoyl)-naphthalene-3-carboxylic acid

HRID 1248100

反応式

HRID 1248100 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]2[C:11]([O:13][C:14](=[O:15])[C:2]=12)=[O:12].[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[Cl-].[Al+3].[Cl-].[Cl-]>O>[F:16][C:17]1[CH:22]=[CH:21][C:20]([C:11]([C:3]2[C:2]([C:14]([OH:13])=[O:15])=[CH:1][C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=2)=[O:12])=[CH:19][CH:18]=1

参加物

5

反応物 3

HCID 10008FluorobenzeneHCID 69743Naphtho(2,3-c)furan-1,3-dioneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 233109402-(4-Fluorobenzoyl)-naphthalene-3-carboxylic acid収率 113.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

45.0 g (227 mmols) of 2,3-naphthalenedicarboxylic anhydride are suspended in 200 ml (2.1 mols) of fluorobenzene, and in the course of 5 minutes, with vigorous stirring, 75.5 g (565 mmols) of powdered aluminium chloride are added (exothermic reaction up to about 32° C.). The dark-red suspension is refluxed and stirred for 6 hours, and the solution is then allowed to cool to room temperature; it is subsequently poured onto about 500 g of ice, and is stirred until completion of hydrolysis. Excess fluorobenzene is evaporated off, and the product obtained is suspended in water. The suspension is filtered off, the filtrate is afterwards washed and the product is dried. There are obtained 76 g of crude 2-(4-fluorobenzoyl)-naphthalene-3-carboxylic acid. The crude product is stirred up with 2 liters of 10% sodium carbonate solution; the resulting solution is then acidified with hydrochloric acid, and the white precipitate is filtered off and dried. The yield is 54.2 g (81% of theory) of 2-(4-fluorobenzoyl)-naphthalene-3-carboxylic acid. MS: (M+ =294; M+ --COOH=249, M+ --COO=250, M+ --C6H4F=199); IR spectrum (KBr): OH about 3300 cm-1 ; C=O double bands 1695/1705 cm-1.

後処理

  1. custom(exothermic reaction up to about 32° C.)
  2. temperatureThe dark-red suspension is refluxed
  3. stirringis stirred until completion of hydrolysis
  4. customExcess fluorobenzene is evaporated off
  5. customthe product obtained
  6. filtrationThe suspension is filtered off
  7. washthe filtrate is afterwards washed
  8. customthe product is dried

出典と根拠

ORDレコード
ord-c3618146f81141d880ec1f4e0c7fccc8
出典データセット
uspto-grants-1985_06
特許番号
US04522754

関連ノート

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