Potassium Hydroxide → HCID 20279048、化合物

HRID 1248193ノート

反応式

HRID 1248193 の反応式
[CH2:1]([C:5]([CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)([C:11]([O:13]CC)=[O:12])[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[K+]>O.CO>[CH2:1]([C:5]([CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)([C:11]([OH:13])=[O:12])[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 20279073HCID 20279073、化合物

生成物 1

HCID 20279048HCID 20279048、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

A mixture of diethyl 2-n-butyl-2-(cyclohexylmethyl)malonate (1.8 g) and potassium hydroxide (10 g) in water (10 ml) and methanol (10 ml) were heated under reflux for 4 hours. The methanol was evaporated under reduced pressure and the residue treated with water (50 ml), cooled to 0° C., and acidified with concentrated hydrochloric acid. The product was extracted with ethyl acetate and the extracts washed with brine, dried (MgSO4) and evaporated to give 2-n-butyl-2-(cyclohexylmethyl)malonic acid. Without further purification the acid was heated to about 160° until the evolution of carbon dioxide ceased, and cooled to give 2-(cyclohexylmethyl)hexanoic acid.

後処理

  1. temperaturewere heated
  2. temperatureunder reflux for 4 hours
  3. customThe methanol was evaporated under reduced pressure
  4. additionthe residue treated with water (50 ml)
  5. extractionThe product was extracted with ethyl acetate
  6. washthe extracts washed with brine
  7. dry with materialdried (MgSO4)
  8. customevaporated

出典と根拠

ORDレコード
ord-c6a1997e27b145ceae233f77a97c5dbc
出典データセット
uspto-grants-1985_06
特許番号
US04522948

反応ノート

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