Ethyl 2-formyl-3-(3,4,5-trimethoxyphenyl)propanoate → HCID 20279268、化合物
反応式
[CH:1]([CH:3]([CH2:9][C:10]1[CH:15]=[C:14]([O:16][CH3:17])[C:13]([O:18][CH3:19])=[C:12]([O:20][CH3:21])[CH:11]=1)[C:4](OCC)=O)=[O:2].[N+:22]([NH:25][C:26]([NH2:28])=[NH:27])([O-:24])=[O:23].C[O-].[Na+]>CO>[N+:22]([NH:25][C:26]1[NH:28][C:1](=[O:2])[C:3]([CH2:9][C:10]2[CH:15]=[C:14]([O:16][CH3:17])[C:13]([O:18][CH3:19])=[C:12]([O:20][CH3:21])[CH:11]=2)=[CH:4][N:27]=1)([O-:24])=[O:23]参加物
5
実験手順
Crude ethyl 2-formyl-3-(3,4,5-trimethoxyphenyl)propionate (7.41 g) was reacted with nitroguanidine (2.62 g) and sodium methoxide in refluxing methanol for 40 hours to give 2-nitroamino-5-(3,4,5-trimethoxybenzyl)-4-pyrimidone in 13% yield.