Boron tribromide → 5-Hydroxybenzocyclobutene-1-carboxylic acid methyl ester

HRID 1248363ノート

反応式

HRID 1248363 の反応式
B(Br)(Br)Br.[CH3:5][O:6][C:7]([C:9]1[C:12]2[CH:13]=[C:14]([O:17]C)[CH:15]=[CH:16][C:11]=2[CH:10]=1)=[O:8]>ClCCl>[CH3:5][O:6][C:7]([C:9]1[C:12]2[CH:13]=[C:14]([OH:17])[CH:15]=[CH:16][C:11]=2[CH:10]=1)=[O:8]

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 541184135-Methoxybenzocyclobutene-1-carboxylic acid methyl ester

生成物 1

HCID 536353185-Hydroxybenzocyclobutene-1-carboxylic acid methyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1000 ml of a 1-molar solution of boron tribromide in dichloromethane are poured over 19.5 g of 5-methoxybenzocyclobutene-1-carboxylic acid methyl ester and the whole is heated at reflux for 6 hours. The whole is concentrated to dryness by evaporation and extracted by shaking with a mixture of 2000 ml of dichloromethane and 1000 ml of water and the organic phase is separated off, washed with water, dried over magnesium sulphate and concentrated to dryness by evaporation. 5-hydroxybenzocyclobutene-1-carboxylic acid methyl ester is obtained in the form of white crystals having a melting point of 108°-109° (from ether/hexane).

後処理

  1. temperaturethe whole is heated
  2. temperatureat reflux for 6 hours
  3. concentrationThe whole is concentrated to dryness by evaporation
  4. extractionextracted
  5. customthe organic phase is separated off
  6. washwashed with water
  7. dry with materialdried over magnesium sulphate
  8. concentrationconcentrated to dryness by evaporation

出典と根拠

ORDレコード
ord-9a66093b66e84320ab9db742667f478b
出典データセット
uspto-grants-1985_06
特許番号
US04523030

反応ノート

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