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5-(3-Pyridylmethyl)-4-pyrimidone → 2-[[4-[[5-[(Dimethylamino)methyl]-2-furanyl]methoxy]butyl]amino]-5-[(3-pyridinyl)methyl]-4(3H)-pyrimidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(3-Pyridylmethyl)-4-pyrimidone | HCID 20448177 | — |
| 反応物 | 5-[(4-Aminobutoxy)methyl]-N,N-dimethyl-2-furanmethanamine | HCID 21297583 | — |
| 生成物 | 2-[[4-[[5-[(Dimethylamino)methyl]-2-furanyl]methoxy]butyl]amino]-5-[(3-pyridinyl)methyl]-4(3H)-pyrimidinone | HCID 20277884 | 52.2% |
反応手順
A mixture of 5-[(4-aminobutoxy)methyl]-N,N-dimethyl-2-furanmethanamine (1 g) and 2-methylthio)-5-[(3-pyridinyl)methyl]-4(3H)-pyrimidinone (1 g) was heated at 140° for 7 h. Column chromatography (silica/methanol) of the residue yielded the title compound (0.95 g) as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04524071 |
| 出典データセット | uspto-grants-1985_06 |
| ORD ID | ord-0641ff2f19e949608b077180c477192a |
| 出典メモ | uspto-grants-1985_06 |