Fumaric Acid → HCID 20277151、化合物

HRID 1248647ノート

反応式

HRID 1248647 の反応式
[CH3:1][C:2]1([CH3:16])[CH:7]2[CH2:8][CH:3]1[CH2:4][CH2:5][CH:6]2[CH2:9][CH2:10][N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1.[C:17]([OH:24])(=[O:23])/[CH:18]=[CH:19]/[C:20]([OH:22])=[O:21]>C(O)C>[C:17]([OH:24])(=[O:23])/[CH:18]=[CH:19]/[C:20]([OH:22])=[O:21].[CH3:1][C:2]1([CH3:16])[CH:7]2[CH2:8][CH:3]1[CH2:4][CH2:5][CH:6]2[CH2:9][CH2:10][N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1

参加物

4

反応物 2

HCID 444972Fumaric AcidHCID 20277152HCID 20277152、化合物

生成物 1

HCID 20277151HCID 20277151、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A solution of 1-[2-(6,6-dimethylbicyclo[3.1.1]heptan-2-yl)ethyl]imidazole (0.8 g, 3.67 mmol) in hot ethanol (20 ml) was added to a solution of fumaric acid (0.39 g, 3.36 mmol) in hot ethanol (20 ml). After boiling for 0.15 h, the mixture was concentrated to afford a white solid. Recrystallisation of the solid from ethyl acetate afforded 1-[2-(6,6-dimethylbicyclo[3.1.1]heptan-2-yl)ethyl]imidazole hydrogen fumarate, m.p. 100°-102°.

後処理

  1. concentrationthe mixture was concentrated
  2. customto afford a white solid
  3. customRecrystallisation of the solid from ethyl acetate

出典と根拠

ORDレコード
ord-f1b624a086b84bd6822656432a751726
出典データセット
uspto-grants-1985_06
特許番号
US04525475

反応ノート

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