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Saccharin → 4-trifluoroacetoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Saccharin | HCID 5143 | — |
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Trifluoromethanesulfonic acid | HCID 62406 | — |
| 反応物 | 4-hydroxy-1H-1,2-benzisothiazole-1,1,3(2H)-trione | HCID 1486522 | — |
| 生成物 | 4-trifluoroacetoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide | HCID 54372980 | — |
反応手順
The specification describes a process for preparing 4-hydroxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide, a sweetener, from 1,2-benzisothiazol-3(2H)-one-1,1-dioxide by anodic oxidation in the presence of trifluoroacetic acid or trifluoromethanesulfonic acid and, optionally, in the presence of salts which increase the conductivity. The oxidation is effected in an anhydrous medium and the 4-trifluoroacetoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide formed as an intermediate when, for example, trifluoroacetic acid is used is decomposed with water to obtain the desired end product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04626325 |
| 出典データセット | uspto-grants-1986_12 |
| ORD ID | ord-aa6994a49181462785998d04c8f4aa4f |
| 出典メモ | uspto-grants-1986_12 |