Triethylamine → HCID 54396231、化合物

HRID 1248787ノート

反応式

HRID 1248787 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([OH:17])[CH:10]=1)=[O:7].[CH2:18](OC1C=C(O)C=CC=1OC)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(N(CC)CC)C.O1C=CC=C1C(Cl)=O>CN(C)C1C=CN=CC=1.C(Cl)Cl>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:10]=1)=[O:7]

参加物

7

反応物 4

HCID 8471TriethylamineHCID 682422-Furancarbonyl chlorideHCID 135310983-(Benzyloxy)-4-methoxyphenolHCID 536654323-Hydroxy-4-methoxyphenyl 2-furancarboxylate

生成物 1

HCID 54396231HCID 54396231、化合物

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

The compound 3-hydroxy-4-methoxyphenyl 2-furoate was made as follows. An amount of 2.00 gms. of 3-benzyloxy-4-methoxyphenol, 1.00 gms. of triethylamine and 0.10 gms of 4-dimethylaminopyridine were dissolved in 100 ml. of methylene chloride at 0° C. and stirred. To the mixture was added 1.16 gms. of 2-furoyl chloride and the mixture was stirred overnight. The mixture was then washed with equal volumes of 1M hydrochloric acid, saturated sodium bicarbonate and water. The mixture was then dried over magnesium sulfate and the solvent evaporated to yield 3-benzyloxy-4-methoxyphenyl 2-furoate.

後処理

  1. additionTo the mixture was added 1.16 gms
  2. washThe mixture was then washed with equal volumes of 1M hydrochloric acid, saturated sodium bicarbonate and water
  3. dry with materialThe mixture was then dried over magnesium sulfate
  4. customthe solvent evaporated

出典と根拠

ORDレコード
ord-16a9c73d18f746df95317f6d5d164f3c
出典データセット
uspto-grants-1986_12
特許番号
US04626442

反応ノート

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