(S)-2-(Acetoxyacetyl)-1-(tert-butoxycarbonyl)pyrrolidine → 2(s)-(Acetoxyacetyl)-pyrrolidine trifluoroacetic acid salt
反応式
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[C:13](=[O:19])[CH2:14][O:15][C:16](=[O:18])[CH3:17])=O)(C)(C)C.[F:20][C:21]([F:26])([F:25])[C:22]([OH:24])=[O:23].C(O)(=O)C>>[F:20][C:21]([F:26])([F:25])[C:22]([OH:24])=[O:23].[C:16]([O:15][CH2:14][C:13]([C@@H:9]1[CH2:10][CH2:11][CH2:12][NH:8]1)=[O:19])(=[O:18])[CH3:17]参加物
3
実験手順
A solution of 1.00 g of the product of Example 2 can be kept in 10 ml of 1:1 trifluoracetic acid-acetic acid at 20° for 30 minutes. The solvents can then be removed under reduced pressure to give (S)-2-(2-acetoxy-1-oxoethyl)-pyrrolidine trifluoracetate.
後処理
- customThe solvents can then be removed under reduced pressure
出典と根拠
- ORDレコード
- ord-7fa09c580400450d840324a66d338ebb
- 出典データセット
- uspto-grants-1986_12
- 特許番号
- US04626545
反応ノート
読み込み中…