Methanesulfonic Acid → 8-Chloro-5-nitroacridine-2,9-diol

HRID 1248831ノート

反応式

HRID 1248831 の反応式
[Cl:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([O:17]CC4C=CC=CC=4)[CH:12]=3)[NH:7][C:6]=2[C:5]([N+:25]([O-:27])=[O:26])=[CH:4][CH:3]=1.CS(O)(=O)=O>C(O)(=O)C>[Cl:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([OH:17])[CH:12]=3)[NH:7][C:6]=2[C:5]([N+:25]([O-:27])=[O:26])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6395Methanesulfonic AcidHCID 135883221-Chloro-4-nitro-7-(phenylmethoxy)-9(10H)-acridinone

生成物 1

HCID 135882308-Chloro-5-nitroacridine-2,9-diol

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a stirred and boiling mixture of 26.7 g of 1-chloro-4-nitro-7-(phenylmethoxy)-9(10H)-acridinone in 1.9 l of glacial acetic acid was added 13.0 ml of methanesulfonic acid. Heating and stirring were continued for seven hours and the mixture was filtered. The precipitate was suspended in 250 ml of boiling glacial acetic acid, cooled to 60°, collected, washed with water and then methanol, and dried providing the title compound, mp above 325° C.

後処理

  1. temperatureHeating
  2. stirringstirring
  3. filtrationthe mixture was filtered
  4. temperaturecooled to 60°
  5. customcollected
  6. washwashed with water
  7. dry with materialmethanol, and dried

出典と根拠

ORDレコード
ord-706d21d94aac4a13903d4d70fe288ebf
出典データセット
uspto-grants-1986_12
特許番号
US04626540

反応ノート

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