N,N-Dimethylaniline → 1-Chloro-4-nitro-7-(phenylmethoxy)-9(10H)-acridinone

HRID 1248833ノート

反応式

HRID 1248833 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[C:7]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:17][CH:16]=2)[C:3]=1[C:4](O)=[O:5].CN(C)C1C=CC=CC=1.P(Cl)(Cl)(Cl)=O>ClCCCl>[Cl:1][C:2]1[C:3]2[C:4](=[O:5])[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH:19]=3)[NH:14][C:7]=2[C:8]([N+:11]([O-:13])=[O:12])=[CH:9][CH:10]=1

参加物

5

反応物 3

HCID 949N,N-DimethylanilineHCID 24813Phosphorus oxychlorideHCID 13588229HCID 13588229、化合物

生成物 1

HCID 135883221-Chloro-4-nitro-7-(phenylmethoxy)-9(10H)-acridinone

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

Four grams of 2-chloro-5-nitro-6-[[4-(phenylmethoxy)phenyl]amino]benzoic acid was suspended in 80 ml of boiling 1,2-dichloroethane to which 0.2 ml of N,N-dimethylaniline was added followed by 8.0 ml of phosphorus oxychloride. The mixture was stirred under reflux for 30 minutes and cooled overnight. The resulting suspension was filtered providing the title compound as a red solid, mp 216°-217° C.

後処理

  1. additionwas added
  2. temperatureunder reflux for 30 minutes
  3. temperaturecooled overnight
  4. filtrationThe resulting suspension was filtered

出典と根拠

ORDレコード
ord-e7d21bc4d78845a6a4ba72571a10a7fd
出典データセット
uspto-grants-1986_12
特許番号
US04626540

反応ノート

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