Ammonia → HCID 13649692、化合物
反応式
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]=[C:4]([NH:9][CH2:10][CH2:11][CH2:12][O:13][CH3:14])[N:3]=1.[NH3:15]>O1CCOCC1>[NH2:15][C:6]1[CH:7]=[C:2]([Cl:1])[N:3]=[C:4]([NH:9][CH2:10][CH2:11][CH2:12][O:13][CH3:14])[N:5]=1参加物
4
実験手順
10 g (0.042 mole) of 4,6-dichloro-2-(3-methoxypropylamino)-pyrimidine are dissolved in 100 ml of dioxane and 60 ml of aqueous ammonia solution are added. After the reaction mixture has been heated to the boil for four hours, it is mixed with 1 liter of ice water and extracted with methylene chloride. The extract is dried over sodium sulphate and concentrated, and the residue which remains is boiled up with white spirit, filtered off and dried. 5.6 g (61.6% of theory) of the desired pyrimidine, melting point 141° C., are obtained.
後処理
- temperatureAfter the reaction mixture has been heated to the boil for four hours
- extractionextracted with methylene chloride
- dry with materialThe extract is dried over sodium sulphate
- concentrationconcentrated
- filtrationfiltered off
- customdried
出典と根拠
- ORDレコード
- ord-333677121e9846a6812a0b3a2f868ed8
- 出典データセット
- uspto-grants-1986_12
- 特許番号
- US04627872
反応ノート
読み込み中…