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Ethanol → (3R)-2-[(3,4-Dichlorobenzylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Carbon Disulfide | HCID 6348 | — |
| 反応物 | 3,4-Dichlorobenzyl chloride | HCID 7609 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid | HCID 675102 | — |
| 生成物 | (3R)-2-[(3,4-Dichlorobenzylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid | HCID 13561937 | 51% |
反応手順
In the same manner as described in Example 16, (3R)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (3.24 g), KOH (1.75 g), 70% ethanol (45 ml), carbon disulfide (0.88 ml) and 3,4-dichlorobenzyl chloride (3.52 g) are reacted and treated. The product is purified by silica gel column chromatography (solvent, chloroform:methanol:acetic acid=97:2:1) to give the title compound (3.37 g, 51%), as pale yellow powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04628057 |
| 出典データセット | uspto-grants-1986_12 |
| ORD ID | ord-274e0d2019404554948768c523a8e926 |
| 出典メモ | uspto-grants-1986_12 |