Sulfuric Acid → HCID 178447982、化合物

HRID 1249304ノート

反応式

HRID 1249304 の反応式
[H-].C([Al+]CC(C)C)C(C)C.[CH2:11]([C@H:14]1[CH2:19][CH2:18][C@H:17]([CH2:20][CH2:21][C@H:22]2[CH2:27][CH2:26][C@H:25]([C:28]#N)[CH2:24][CH2:23]2)[CH2:16][CH2:15]1)[CH2:12][CH3:13].S(=O)(=O)(O)[OH:31]>C1(C)C=CC=CC=1>[CH2:11]([C@H:14]1[CH2:19][CH2:18][C@H:17]([CH2:20][CH2:21][C@H:22]2[CH2:27][CH2:26][C@H:25]([CH:28]=[O:31])[CH2:24][CH2:23]2)[CH2:16][CH2:15]1)[CH2:12][CH3:13]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 21225700DiisobutylaluminumhydrideHCID 178447981HCID 178447981、化合物

生成物 1

HCID 178447982HCID 178447982、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

反応条件

温度
0 °C

実験手順

24 ml of a 1.2M solution of diisobutylaluminium hydride in toluene were added dropwise over a period of 30 minutes at 0° C. and under an inert gas atmosphere to a solution of 5.5 g of trans-4-[2-(trans-4-propylcyclohexyl)ethyl]cyclohexanecarbonitrile in 500 ml of toluene. The mixture was stirred at 0° C. for another hour and then at room temperature for 3 hours. The mixture was subsequently poured into 500 ml of 0.5N sulphuric acid and extracted three times with 200 ml of diethyl ether each time. The combined organic phases were washed first with saturated sodium hydrogen carbonate solution and then with water, dried over sodium sulphate and concentrated, thereby obtaining 5.6 g of trans-4-[2-(trans-4-propylcyclohexyl)ethyl]cyclohexanecarboxaldehyde.

後処理

  1. extractionextracted three times with 200 ml of diethyl ether each time
  2. washThe combined organic phases were washed first with saturated sodium hydrogen carbonate solution
  3. dry with materialwith water, dried over sodium sulphate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-d590212cc2a348678932e23299701768
出典データセット
uspto-grants-1986_12
特許番号
US04630896

反応ノート

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