Potassium Iodide → HCID 13090791、化合物
反応式
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH2:13]Cl.[C-]#N.[K+].[I-].[K+].[CH3:20][N:21](C)C=O>O>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH2:13][C:20]#[N:21]参加物
6
実験手順
49 parts of 3,7-dichloro-8-chloromethylquinoline (Example 1), 13 parts of potassium cyanide and 0.1 part of potassium iodide in 300 parts of dimethylformamide were heated at 150° C. for 4 hours. Water was added to the reaction solution and the precipitated product was filtered off with suction and recrystallized from methylglycol. 32 parts of 3,7-dichloro-8-cyanomethylquinoline of melting point 152° C. were obtained. The yield corresponds to 67% of theory.
後処理
- filtrationthe precipitated product was filtered off with suction
- customrecrystallized from methylglycol
出典と根拠
- ORDレコード
- ord-6939bbb304e9499786a930eff7a46c22
- 出典データセット
- uspto-grants-1986_12
- 特許番号
- US04632696
反応ノート
読み込み中…