Toluene → Pentafluorobenzyltriphenylphosphonium bromide

HRID 1249649

反応式

HRID 1249649 の反応式
C1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)C=CC=CC=1.[F:20][C:21]1[C:26](C[Br:28])=[C:25]([F:29])[C:24]([F:30])=[C:23]([F:31])[C:22]=1[F:32].[C:33]1([CH3:39])[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[Br-:28].[F:29][C:25]1[C:26]([P+:7]([CH2:39][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[C:21]([F:20])[C:22]([F:32])=[C:23]([F:31])[C:24]=1[F:30]

参加物

4

反応物 3

HCID 1140TolueneHCID 11776TriphenylphosphineHCID 74484Pentafluorobenzyl bromide

生成物 1

HCID 87730649Pentafluorobenzyltriphenylphosphonium bromide収率 90%

実験手順

A five-liter, three-necked flask equipped with a mechanical stirrer, reflux condenser, and thermometer was charged with toluene (3.3 liters), triphenylphosphine (686 g, 2.62 mole), and pentafluorobenzyl bromide (343 g, 1.31 mole). The contents were stirred and heated slowly to reflux. A white precipitate formed as the reaction progressed. At the completion of the reaction the flask was cooled to ambient temperature and the solid product was filtered and washed with hot toluene (2.6 liters). These solids were dried in a vacuum desiccator to give a 90% yield of pentafluorobenzyltriphenylphosphonium bromide.

後処理

  1. customA five-liter, three-necked flask equipped with a mechanical stirrer
  2. temperaturereflux condenser
  3. temperatureheated slowly
  4. temperatureto reflux
  5. customA white precipitate formed as the reaction
  6. customAt the completion of the reaction the flask
  7. filtrationthe solid product was filtered
  8. washwashed with hot toluene (2.6 liters)
  9. customThese solids were dried in a vacuum desiccator

出典と根拠

ORDレコード
ord-17688f8e310142d09b1573f1989d69f4
出典データセット
uspto-grants-1986_12
特許番号
US04633020

関連ノート

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