Methanol → HCID 18396724、化合物

HRID 1249658ノート

反応式

HRID 1249658 の反応式
[CH2:1]([NH:13][C:14]([N:16]1[CH:20]=[CH:19]N=[CH:17]1)=[O:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].CNC[C@@H:24]([C@H:26]([C@@H:28]([C@@H:30](CO)[OH:31])[OH:29])[OH:27])[OH:25].C[OH:35]>>[CH2:1]([NH:13][C:14]([N:16]([CH3:17])[CH2:20][C@@H:19]([C@H:24]([C@@H:26]([C@@H:28]([CH2:30][OH:31])[OH:29])[OH:27])[OH:25])[OH:35])=[O:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

参加物

4

反応物 3

HCID 887MethanolHCID 8567N-Methyl-D-glucamineHCID 18328494HCID 18328494、化合物

生成物 1

HCID 18396724HCID 18396724、化合物収率 80%

実験手順

42 g of 1-N-(dodecylaminocarbonyl)imidazole and 32 g of N-methyl-D-glucamine were suspended, under an inert atmosphere, in 400 cm3 of methanol. The reaction mixture was kept stirring at reflux for 4 hours. The reaction mixture was cooled with an ice bath and the precipitate was then filtered off. It was washed with 500 cm3 of water and then dried. 49 g (80% yield) of N-dodecylaminocarbonyl-N-methyl-D-glucamine were obtained in the form of a white powder.

後処理

  1. temperatureat reflux for 4 hours
  2. temperatureThe reaction mixture was cooled with an ice bath
  3. filtrationthe precipitate was then filtered off
  4. washIt was washed with 500 cm3 of water
  5. customdried

出典と根拠

ORDレコード
ord-6c3d0a2f0fc447b6b9ad64db243ca2e6
出典データセット
uspto-grants-2002_01
特許番号
US06335024B2

反応ノート

読み込み中…