HCID 53962035、化合物 → methyl 4-chloro-1H-indole-2-carboxylate

HRID 1249927ノート

反応式

HRID 1249927 の反応式
[N:1]([C:4](=[CH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[Cl:16])[C:5]([O:7][CH3:8])=[O:6])=[N+]=[N-]>C1(C)C=CC=CC=1>[CH3:8][O:7][C:5]([C:4]1[NH:1][C:15]2[C:10]([CH:9]=1)=[C:11]([Cl:16])[CH:12]=[CH:13][CH:14]=2)=[O:6]

参加物

3

反応物 1

HCID 53962035HCID 53962035、化合物

生成物 1

HCID 4714974methyl 4-chloro-1H-indole-2-carboxylate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Methyl 2-azido-3-(2-chlorophenyl)-propenoate (3.566 g, 144 mmol) was suspended in toluene (800 ml) and the mixture was heated at reflux for three hours, then cooled and allowed to stir at room temperature overnight. A yellow crystalline material was obtained by filtration and recrystallised from hexane.

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux for three hours
  3. temperaturecooled
  4. customA yellow crystalline material was obtained by filtration
  5. customrecrystallised from hexane

出典と根拠

ORDレコード
ord-9fbec446f6ef4eada94f1b9e25d08cbe
出典データセット
uspto-grants-2002_01
特許番号
US06335360B1

反応ノート

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