Acetic Acid → 4-Phenyl-1-(4-carboxyphenyl)piperidine

HRID 1249977

反応式

HRID 1249977 の反応式
[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17]C(C#N)=[CH:15][CH:14]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[C:22]([OH:25])(=[O:24])[CH3:23]>>[C:1]1([CH:7]2[CH2:8][CH2:9][N:10]([C:13]3[CH:18]=[CH:17][C:23]([C:22]([OH:25])=[O:24])=[CH:15][CH:14]=3)[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 180010564-Phenyl-1-(4-cyanophenyl)piperidine

生成物 1

HCID 180010494-Phenyl-1-(4-carboxyphenyl)piperidine

実験手順

To 4-phenyl-1-(4-cyanophenyl)piperidine (0.39 g) are added acetic acid (10 ml) and conc. hydrochloric acid (10 ml), and the mixture is refluxed for five hours. The reaction solution is concentrated, and to the residue is added diethyl ether/methanol. The insoluble crystals are collected by filtration, and dried under reduced pressure to give 4-phenyl-1-(4-carboxyphenyl)piperidine (0.39 g) as white powder.

後処理

  1. temperaturethe mixture is refluxed for five hours
  2. concentrationThe reaction solution is concentrated
  3. additionto the residue is added diethyl ether/methanol
  4. filtrationThe insoluble crystals are collected by filtration
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-a5a20b236748481cb3c748029857654f
出典データセット
uspto-grants-2002_01
特許番号
US06335327B1

関連ノート

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