3-(4-oxocyclohexyl)-1H-indole-5-carbonitrile → 8-{4-[4-(5-Cyano-1H-indol-3-yl)-cyclohexyl]-[1,4]diazepan-1-yl}-quinoline

HRID 1250158

反応式

HRID 1250158 の反応式
[N:1]1([C:8]2[CH:9]=[CH:10][CH:11]=[C:12]3[C:17]=2[N:16]=[CH:15][CH:14]=[CH:13]3)[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.O=[C:19]1[CH2:24][CH2:23][CH:22]([C:25]2[C:33]3[C:28](=[CH:29][CH:30]=[C:31]([C:34]#[N:35])[CH:32]=3)[NH:27][CH:26]=2)[CH2:21][CH2:20]1>>[C:34]([C:31]1[CH:32]=[C:33]2[C:28](=[CH:29][CH:30]=1)[NH:27][CH:26]=[C:25]2[CH:22]1[CH2:21][CH2:20][CH:19]([N:4]2[CH2:5][CH2:6][CH2:7][N:1]([C:8]3[CH:9]=[CH:10][CH:11]=[C:12]4[C:17]=3[N:16]=[CH:15][CH:14]=[CH:13]4)[CH2:2][CH2:3]2)[CH2:24][CH2:23]1)#[N:35]

参加物

3

反応物 2

HCID 112418863-(4-oxocyclohexyl)-1H-indole-5-carbonitrileHCID 183273058-[1,4]Diazepan-1-yl-quinoline

生成物 1

HCID 98037858-{4-[4-(5-Cyano-1H-indol-3-yl)-cyclohexyl]-[1,4]diazepan-1-yl}-quinoline収率 92%

実験手順

The title compound was prepared according to Example 3, Step 4 except that 8-[1,4]diazepan-1-yl-quinoline was used instead of 1-(2-methoxy-phenyl)-[1,4]diazepane and 3-(4-oxo-cyclohexyl)-1H-indole-5-carbonitrile was used in place of 4-(5-fluoro-1H-3-indolyl)-cyclohexanone. Yield: 92%; MS (ES) m/z (relative intensity): 450 (M++H, 100).

出典と根拠

ORDレコード
ord-3e71107f37d642c8a1077d7804c6eb38
出典データセット
uspto-grants-2002_01
特許番号
US06337326B1

関連ノート

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