化工社化工社 化学情報印刷レポート · 研究参考用
Benzyl Bromide → N-Benzylnormechlorethamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Bis(2-chloroethyl)amine hydrochloride | HCID 522769 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | N-Benzylnormechlorethamine | HCID 5928 | — |
反応手順
Bis-(2-chloro-ethyl)-amine hydrochloride was suspended in 150 mL acetonitrile. Added were 34.8 g K2CO3 (3 equiv.) and 10.0 mL benzylbromide (1 equiv.). The mixture was refluxed overnight, Concentration on silica and purification with flash column chromatography (eluents PA:ether=95:5) yielded 4.11 g of a colorless oil. 1H NMR (400 MHz, CDCl3) δ 2.93 (t, J=7 Hz, 4H), 3.50 (t, J=7 Hz, 4H), 3.74 (s, 2H), 7.22-7.37 (m, 5H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728018B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-bb9528bd65444948971ae1d9ea7916a5 |
| 出典メモ | uspto-grants-2010_06 |