Allylamine → 2-Allylamino-4-isopropylamino-6-nitroquinazoline hydrochloride

HRID 1250583

反応式

HRID 1250583 の反応式
[Cl:1][C:2]1[N:11]=[C:10]([NH:12][CH:13]([CH3:15])[CH3:14])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:16]([O-:18])=[O:17])[CH:8]=2)[N:3]=1.[CH2:19]([NH2:22])[CH:20]=[CH2:21]>O>[ClH:1].[CH2:19]([NH:22][C:2]1[N:11]=[C:10]([NH:12][CH:13]([CH3:15])[CH3:14])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:16]([O-:18])=[O:17])[CH:8]=2)[N:3]=1)[CH:20]=[CH2:21]

参加物

4

反応物 2

HCID 7853AllylamineHCID 183264282-Chloro-4-isopropylamino-6-nitroquinazoline

生成物 1

HCID 183265012-Allylamino-4-isopropylamino-6-nitroquinazoline hydrochloride

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 870 mg (3.26 mmol) of 2-chloro-4-isopropylamino-6-nitroquinazoline was added 3.81 g (66.64 mmol) of allylamine, followed by stirring at room temperature for 4 hours. To the reaction solution was added water, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 895 mg (yield: 95.7%) of a free base compound of the title compound.

後処理

  1. extractionfollowed by extraction with ethyl acetate
  2. washwashing with brine
  3. dry with materialdrying over anhydrous sodium sulfate
  4. distillationAfter the solvent was distilled off
  5. customthe residue was purified by a silica gel column

出典と根拠

ORDレコード
ord-3452785b83ad483896bc3e4eef052c71
出典データセット
uspto-grants-2002_01
特許番号
US06339089B2

関連ノート

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