Morpholine → 4-(1,3-Thiazol-2-yl)morpholine

反応式

Br[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[NH:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1>>[N:7]1([C:2]2[S:3][CH:4]=[CH:5][N:6]=2)[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1

参加物

反応物 2

HCID 8083Morpholine

HCID 764302-Bromothiazole

生成物 1

HCID 154758374-(1,3-Thiazol-2-yl)morpholine収率 95%

反応条件

温度: 100 °C

実験手順

2-Bromothiazole (4.592 g) was added to morpholine (24 ml), and the mixture was stirred at 100° C. for 4 hr. The reaction mixture was partitioned between ethyl acetate and water. The resulting organic layer was washed with water, dried (over MgSO4) and evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane system) to give the title compound as a pale yellow oil (4.531 g, yield; 95%).

後処理

customThe reaction mixture was partitioned between ethyl acetate and water
washThe resulting organic layer was washed with water
dry with materialdried (over MgSO4)
customevaporated
customThe resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane system)

出典と根拠

ORDレコード: ord-ce19671af04d48fe811a37ff46e7b8ac
出典データセット: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06340759B1

反応ノート

読み込み中…

参加物