1-Ethylpiperazine → 6-Bromo-8-(1-ethylpiperazin-4-yl)-1,7-naphthyridine

HRID 1251157ノート

反応式

HRID 1251157 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10](Br)[N:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.[CH2:13]([N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[CH3:14]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([N:18]3[CH2:19][CH2:20][N:15]([CH2:13][CH3:14])[CH2:16][CH2:17]3)[N:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2

参加物

3

反応物 2

HCID 791961-EthylpiperazineHCID 225032286,8-Dibromo-1,7-naphthyridine

生成物 1

HCID 225032736-Bromo-8-(1-ethylpiperazin-4-yl)-1,7-naphthyridine収率 98%

反応条件

温度
100 °C

実験手順

6,8-Dibromo-1,7-naphthyridine (3.464 g) was added to 1-ethylpiperazine (10 ml), and the resulting mixture was stirred at 100° C. for 15 min. The reaction mixture was evaporated, and then partitioned between ethyl acetate and water. The resulting organic layer was washed with water, dried (over MgSO4) and evaporated. The resulting residue was purified by (NH) silica gel column chromatography (ethyl acetate/hexane system), to give the title compound as a yellowish orange solid (3.780 g, yield; 98%).

後処理

  1. customThe reaction mixture was evaporated
  2. custompartitioned between ethyl acetate and water
  3. washThe resulting organic layer was washed with water
  4. dry with materialdried (over MgSO4)
  5. customevaporated
  6. customThe resulting residue was purified by (NH) silica gel column chromatography (ethyl acetate/hexane system)

出典と根拠

ORDレコード
ord-b62cc567fc674a359b050b04cd825e19
出典データセット
uspto-grants-2002_01
特許番号
US06340759B1

反応ノート

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