Water → HCID 178510922、化合物

HRID 1251179ノート

反応式

HRID 1251179 の反応式
BrC[C:3]1[S:4][CH:5]=[CH:6][C:7]=1[C:8]#[N:9].[C-:10]#[N:11].[Na+].O.C(O[CH2:18][CH3:19])(=O)C>C1(C)C=CC=CC=1>[C:8]([CH2:7][CH2:6][C:5]1[SH:4]([C:10]#[N:11])[CH:3]=[CH:18][CH:19]=1)#[N:9]

参加物

6

反応物 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 8929Sodium CyanideHCID 225036202-(Bromomethyl)thiophene-3-carbonitrile

生成物 1

HCID 178510922HCID 178510922、化合物収率 43%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
80 °C

実験手順

2-Bromomethyl-3-cyanothiophene (2.746 g) was dissolved in toluene (40 ml), followed by the addition of a solution of sodium cyanide (2.002 g)/water (15 ml), and the mixture was stirred at 80° C. overnight. The reaction mixture was diluted with ethyl acetate and washed with an aqueous solution of saturated sodium bicarbonate, dried (over MgSO4) and evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane system), to give the title compound as a pale yellow solid (823 mg, yield; 43%).

後処理

  1. washwashed with an aqueous solution of saturated sodium bicarbonate
  2. dry with materialdried (over MgSO4)
  3. customevaporated
  4. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane system)

出典と根拠

ORDレコード
ord-cd10ed48ad1e4a63bc09b76fa715a435
出典データセット
uspto-grants-2002_01
特許番号
US06340759B1

反応ノート

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