Hydrochloric Acid → 4-(1H-pyrazol-3-yl)aniline

HRID 1251467

反応式

HRID 1251467 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:14][N:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([O-])=O.O.O.[Sn](Cl)Cl.Cl>C(O)C>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[NH:14][N:13]=[CH:12][CH:11]=2)=[CH:8][CH:9]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 61436Stannous chloride dihydrateHCID 27370713-(4-Nitrophenyl)-1H-pyrazole

生成物 1

HCID 27353994-(1H-pyrazol-3-yl)aniline収率 95.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 5-(4-nitrophenyl)pyrazole (10.1 g) in ethanol (100 ml) was added Tin(II) chloride dihydrate (35.7 g) and concentrated hydrochloric acid (25.5 ml). After the addition was completed, the reaction mixture was refluxed for 3 hours. After cooling, the solvent was evaporated and strongly basified (NaOH solution) and then extracted with chloroform. The extract was washed with brine, dried (MgSO4) and evaporated to dryness to obtain the title compound (8.1 g).

後処理

  1. additionAfter the addition
  2. temperaturethe reaction mixture was refluxed for 3 hours
  3. temperatureAfter cooling
  4. customthe solvent was evaporated
  5. extractionstrongly basified (NaOH solution) and then extracted with chloroform
  6. washThe extract was washed with brine
  7. dry with materialdried (MgSO4)
  8. customevaporated to dryness

出典と根拠

ORDレコード
ord-2ee85007c9e44ccab33ddfa300ff1533
出典データセット
uspto-grants-2002_01
特許番号
US06342516B1

関連ノート

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