2-(Methylamino)ethanol → 2-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidine

HRID 1251478ノート

反応式

HRID 1251478 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][NH:11][CH2:12][CH2:13][OH:14]>C(O)C>[Cl:1][C:2]1[N:3]=[C:4]([CH3:9])[CH:5]=[C:6]([N:11]([CH2:12][CH2:13][OH:14])[CH3:10])[N:7]=1

参加物

4

反応物 2

HCID 80162-(Methylamino)ethanolHCID 794712,4-Dichloro-6-methylpyrimidine

生成物 1

HCID 183238282-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidine収率 34.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Part A: A solution of 2,4-dichloro-6-methylpyrimidine (1.0 g) and 2-(methylamino)ethanol (0.4 g) in ethanol (50 mL) was refluxed for 24 hours. The solvent was evaporated to give a crude residue, which was chromatographed on silica gel using 5% methanol in chloroform to yield 2-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidine (370 mg).

後処理

  1. customThe solvent was evaporated
  2. customto give a crude residue, which
  3. customwas chromatographed on silica gel using 5% methanol in chloroform

出典と根拠

ORDレコード
ord-809df0f308944ae4b78afa458d165f64
出典データセット
uspto-grants-2002_01
特許番号
US06342503B1

反応ノート

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