関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Bromotoluene | HCID 7805 | — |
| 反応物 | Triisopropyl borate | HCID 21531 | — |
| 反応物 | Lithium phenylacetylide | HCID 3437284 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 溶媒 | Tetrahydrofuran dimethoxyethane | HCID 22732251 | — |
| 生成物 | Benzene, 1-methyl-4-(phenylethynyl)- | HCID 3014187 | — |
反応手順
General Procedure A. To a solution of lithium phenylacetylide (15.2 ml, 15.2 mmol) in DME (20 ml) under Argon at −78° C. was added triisopropoxylborane (3.5 ml, 15.2 mmol). The mixture was stirred at −78° C. for 1.5 hours. A solution of 1-bromo-4-methylbenzene (2 g, 11.7 mmol) in DME/THF (10 ml/10 ml) was degassed with dry argon, Pd(PPh3)4 (405 mg, 0.35 mmol) was added and the solution was degassed for another 5 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07728014B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-ec8adad63d0041a0969484598bc2e2fd |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
