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Ethyl 5,6-diphenyl-1,2,4-triazine-3-carboxylate → Ethyl 5,6-diphenylpyridine-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 5,6-diphenyl-1,2,4-triazine-3-carboxylate | HCID 317903 | — |
| 反応物 | N-Vinylpyrrolidine | HCID 3014294 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Ethyl 5,6-diphenylpyridine-2-carboxylate | HCID 14789610 | — |
反応手順
General Procedure D. Ethyl 5,6-diphenyl-1,2,4-triazine-3-carboxylate (Compound 11, 200 mg, 0.66 mmol) and crude 1-vinylpyrrolidine (Compound 38, 2 g) in CHCl3 (20 ml) was heated at 75° C. overnight under nitrogen. The solvent was removed in vacuo, and the residue was purified by silica gel column chromatography (20% ethyl acetate in hexane) to yield the title compound as a light yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728014B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-407ba34a62634895800105f14ad97f06 |
| 出典メモ | uspto-grants-2010_06 |