Pulegol → Neoisomenthol

HRID 1251630ノート

反応式

HRID 1251630 の反応式
[CH3:1][CH:2]1[CH2:10][CH:9]([OH:11])[C:5](=[C:6]([CH3:8])[CH3:7])[CH2:4][CH2:3]1>[Pd].[C].C(OCC)(=O)C>[CH3:1][C@H:2]1[CH2:10][C@@H:9]([OH:11])[C@@H:5]([CH:6]([CH3:8])[CH3:7])[CH2:4][CH2:3]1

参加物

4

反応物 1

HCID 92793Pulegol

生成物 1

HCID 19244Neoisomenthol収率 90%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
60 °C

実験手順

A 100 ml capacity autoclave was charged with 1.0 g (6.5 mmol) of pulegol, 5% Pd-carbon (20 mg) and ethyl acetate (5 ml), and the mixture was stirred at 60° C. for 5 hours under a hydrogen pressure of 2 Mpa. After completion of the reaction, the reaction solution was cooled to room temperature and concentrated. A 0.99 g portion of a mixture of menthol:neoisomenthol=91:9 was obtained. The yield was 90%.

後処理

  1. customAfter completion of the reaction
  2. temperaturethe reaction solution was cooled to room temperature
  3. concentrationconcentrated
  4. additionA 0.99 g portion of a mixture of menthol

出典と根拠

ORDレコード
ord-ee8680ab80ff49fab1bb95cf6419c2a8
出典データセット
uspto-grants-2002_01
特許番号
US06342644B1

反応ノート

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