4-Bromo-3-methylisoxazol-5-amine → N-(4-Bromo-3-methyl-5-isoxazolyl)-2-[(4-methylphenoxy)methyl]thiophene-3-sulfonamide

HRID 1251825ノート

反応式

HRID 1251825 の反応式
Cl[S:2]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=1)(=[O:4])=[O:3].[NH2:19][C:20]1[O:24][N:23]=[C:22]([CH3:25])[C:21]=1[Br:26]>>[Br:26][C:21]1[C:22]([CH3:25])=[N:23][O:24][C:20]=1[NH:19][S:2]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=1)(=[O:4])=[O:3]

参加物

3

反応物 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 234452572-[(4-Methylphenoxy)methyl]thiophene-3-sulfonyl chloride

生成物 1

HCID 23445507N-(4-Bromo-3-methyl-5-isoxazolyl)-2-[(4-methylphenoxy)methyl]thiophene-3-sulfonamide収率 64%

実験手順

N-(4-bromo-3-methyl-5-isoxazolyl)-2-[(4-methylphenoxy)methyl]thiophene-3-sulfonamide was prepared, as described in Example 2, by reacting 3-chlorosulfonyl-2-[(4-methylphenoxy)methyl]thiophene with 5-amino-4-bromo-3-methylisoxazole, resulting in a 64% yield, m.p. 128-130° C.

後処理

  1. customresulting in a 64% yield, m.p. 128-130° C.

出典と根拠

ORDレコード
ord-61d4b57a567e4c269a4799562679a72c
出典データセット
uspto-grants-2002_01
特許番号
US06342610B2

反応ノート

読み込み中…