Propanoyl bromide, 2-bromo- → HCID 20140977、化合物

HRID 1252120ノート

反応式

HRID 1252120 の反応式
[NH:1]1[CH2:10][CH2:9][CH2:8][C:7]2[N:6]=[CH:5][C:4]3[CH:11]=[CH:12][CH:13]=[CH:14][C:3]=3[C:2]1=2.[Br:15][CH:16]([CH3:20])[C:17](Br)=[O:18]>C(OCC)C>[BrH:15].[Br:15][CH:16]([CH3:20])[C:17]([N:1]1[CH2:10][CH2:9][CH2:8][C:7]2[N:6]=[CH:5][C:4]3[CH:11]=[CH:12][CH:13]=[CH:14][C:3]=3[C:2]1=2)=[O:18]

参加物

4

反応物 2

HCID 79047Propanoyl bromide, 2-bromo-HCID 138234741,2,3,4-Tetrahydrobenzo[c]-1,5-naphthyridine

生成物 1

HCID 20140977HCID 20140977、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of 15.0 g of 1,2,3,4-tetrahydrobenzo[c]-1,5-naphthyridine in 24 ml of 2-bromopropionyl bromide was stirred overnight at ambient temperature. The solution was then diluted with anhydrous diethyl ether and stirred for approximately 3 hours at ambient temperature. A precipitate separated from the solution. The precipitate was collected by vacuum filtration and dried under vacuum at 40° C. overnight. The solid was recrystallized from a mixture of 95% ethanol and anhydrous diethyl ether (1:2) to yield 28.22 g of a powdery solid.

後処理

  1. customA precipitate separated from the solution
  2. filtrationThe precipitate was collected by vacuum filtration
  3. customdried under vacuum at 40° C. overnight
  4. customThe solid was recrystallized from a mixture of 95% ethanol and anhydrous diethyl ether (1:2)

出典と根拠

ORDレコード
ord-91aa06deed9a46b0a69d7f2922988285
出典データセット
uspto-grants-1988_05
特許番号
US04742061

反応ノート

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