4-Methoxybenzyl alcohol → HCID 20140782、化合物

HRID 1252216

反応式

HRID 1252216 の反応式
[CH3:1][C:2]1([CH3:10])[CH2:8][CH2:7][C:6](=[O:9])[O:5][C:3]1=[O:4].[OH:11][CH2:12][C:13]1[CH:20]=[CH:19][C:16]([O:17][CH3:18])=[CH:15][CH:14]=1.C(N(CC)CC)C>O1CCOCC1>[C:3]([C:2]([CH3:10])([CH3:1])[CH2:8][CH2:7][C:6]([O:11][CH2:12][C:13]1[CH:20]=[CH:19][C:16]([O:17][CH3:18])=[CH:15][CH:14]=1)=[O:9])([OH:5])=[O:4]

参加物

5

反応物 3

HCID 77384-Methoxybenzyl alcoholHCID 8471TriethylamineHCID 76247Dihydro-3,3-dimethyl-2H-pyran-2,6(3H)-dione

生成物 1

HCID 20140782HCID 20140782、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
80 °C

実験手順

A mixture of 2,2-dimethylglutaric anhydride (19.34 g), anise alcohol (22.08 g) and triethylamine (19.39 g) in dry dioxane (360 ml) was stirred at 80° C. for 3.5 hours. The reaction mixture was evaporated and the residue was diluted with water and adjusted to pH 9 with potassium carbonate. The aqueous layer was washed with benzene, acidified with dilute hydrochloric acid and extracted with benzene. The extract was washed with water, dried over anhydrous sodium sulfate and evaporated to give p-methoxybenzyl 4-carboxy-4-methylvalerate.

後処理

  1. customThe reaction mixture was evaporated
  2. additionthe residue was diluted with water
  3. washThe aqueous layer was washed with benzene
  4. extractionextracted with benzene
  5. washThe extract was washed with water
  6. dry with materialdried over anhydrous sodium sulfate
  7. customevaporated

出典と根拠

ORDレコード
ord-b098b3b1ed444003b5fa770d4f851bf6
出典データセット
uspto-grants-1988_05
特許番号
US04742052

関連ノート

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