Ethylamine → Ethyl N-ethyl-beta-alaninate

HRID 1252277

反応式

HRID 1252277 の反応式
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[CH2:3].[CH2:8]([NH2:10])[CH3:9]>C(O)C>[CH2:8]([NH:10][CH2:3][CH2:2][C:1]([O:5][CH2:6][CH3:7])=[O:4])[CH3:9]

参加物

4

反応物 2

HCID 6341EthylamineHCID 8821Ethyl Acrylate

生成物 1

HCID 90223Ethyl N-ethyl-beta-alaninate収率 70%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

50 g (0.50 mole) of ethyl acrylate was dissolved in 500 ml of ethanol. To the resulting solution being stirred in an ice bath was added dropwise a mixed solution consisting of 36 g of a 70% aqueous ethylamine solution (containing 0.55 mole of ethylamine) and 100 ml of ethanol, in 3.5 hours. The reaction was continued for further 3 hours and then the solvent was distilled off. The resulting residue was subjected to vacuum distillation to obtain 50.5 g of a desired product with an yield of 70%.

後処理

  1. additionwas added dropwise a mixed solution
  2. distillationthe solvent was distilled off
  3. distillationThe resulting residue was subjected to vacuum distillation

出典と根拠

ORDレコード
ord-492d6bc4bbf641baa72369207291587a
出典データセット
uspto-grants-1988_05
特許番号
US04742165

関連ノート

読み込み中…