Water → HCID 14209242、化合物

HRID 1252406ノート

反応式

HRID 1252406 の反応式
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1Cl)=[CH:9][CH:8]=[CH:7][CH:6]=2.[OH:13][CH:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:15][NH2:16].O>C(OC(O)C)C>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:16][CH2:15][CH:14]([OH:13])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2

参加物

5

反応物 3

HCID 962WaterHCID 1000PhenylethanolamineHCID 6183063-Bromo-4-chloroquinoline

生成物 1

HCID 14209242HCID 14209242、化合物

試薬・触媒・溶媒 1

HCID 101298981-Ethoxyethanol溶媒

実験手順

A solution of 4 g of 3-bromo-4-chloro-quinoline and 6 g of 2-hydroxy-2-phenyl-ethylamine was heated at 150° C. for 3 hours in 10 ml of ethoxyethanol. The mixture was cooled and poured into 150 ml of water. The product was extracted with two 50 ml portions of ether. The ether layer was dried over sodium sulfate, the solvent was evaporated and the residue was recrystallized from isopropanol. The yield was 3.0 g, mp 131°-132° C.

後処理

  1. temperatureThe mixture was cooled
  2. extractionThe product was extracted with two 50 ml portions of ether
  3. dry with materialThe ether layer was dried over sodium sulfate
  4. customthe solvent was evaporated
  5. customthe residue was recrystallized from isopropanol

出典と根拠

ORDレコード
ord-6d84c292ad194362b91031070ea5fa0c
出典データセット
uspto-grants-1988_05
特許番号
US04743601

反応ノート

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