Ethyl 5,6-diphenylpyridine-2-carboxylate → Methyl 5,6-diphenylpyridine-2-carboxylate

HRID 12525

反応式

HRID 12525 の反応式
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:19]([O:21][CH2:22]C)=[O:20])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>OS(O)(=O)=O.CO.O>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:19]([O:21][CH3:22])=[O:20])=[N:11][C:12]=2[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 1

HCID 14789610Ethyl 5,6-diphenylpyridine-2-carboxylate2 回

生成物 1

HCID 13487992Methyl 5,6-diphenylpyridine-2-carboxylate

試薬・触媒・溶媒 3

HCID 1118Sulfuric Acid触媒HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

General Procedure E. A solution of ethyl 5,6-diphenylpyridine-2-carboxylate (Compound 21, 30 mg, 0.1 mmol) and conc. H2SO4 (3 drops) in MeOH (5 ml) was heated at 50° C. overnight. The mixture was diluted with water, and the products were extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over Na2SO4. The filtered solvent was concentrated in vacuo and the residue was purified by column chromatography (20% ethyl acetate in hexane) to obtain the title compound as a yellow solid.

後処理

  1. extractionthe products were extracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over Na2SO4
  4. concentrationThe filtered solvent was concentrated in vacuo
  5. customthe residue was purified by column chromatography (20% ethyl acetate in hexane)

出典と根拠

ORDレコード
ord-c8ed5a439c8346ba9a574f8b0447231e
出典データセット
uspto-grants-2010_06
特許番号
US07728014B2

関連ノート

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