Triethylamine → [4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl][(4-morpholinyl)thio]amine

HRID 1252675

反応式

HRID 1252675 の反応式
[N:1]1([S:7]Cl)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[F:16][C:17]1[CH:23]=[C:22]([O:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][C:26]=2[Cl:35])[CH:21]=[CH:20][C:18]=1[NH2:19]>C(OCC)C>[Cl:35][C:26]1[CH:27]=[C:28]([C:31]([F:32])([F:34])[F:33])[CH:29]=[CH:30][C:25]=1[O:24][C:22]1[CH:21]=[CH:20][C:18]([NH:19][S:7][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[C:17]([F:16])[CH:23]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 122977794-Morpholinesulfenyl chlorideHCID 15595105Benzenamine, 4-[2-chloro-4-(trifluoromethyl)phenoxy]-2-fluoro-

生成物 1

HCID 15085830[4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl][(4-morpholinyl)thio]amine収率 59.3%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒3 回

実験手順

The compound prepared in Example 5 (3.4 g) was dissolved in diethyl ether (10 ml). The solution was added to a solution of triethylamine (2.2 g) and the compound prepared in Example 1 (6.1 g) in diethyl ether (50 ml) at 15°-20° C. The solution was stirred for 20 minutes, diethyl ether was added (20 ml), the solution was washed with water, and dried. The solvent was removed by evaporation. Column chromatography on silica using 50:50 (v/v) diethyl ether-dichloromethane as eluant yielded the title compound as a brown oil (5 g).

後処理

  1. customat 15°-20° C
  2. washthe solution was washed with water
  3. customdried
  4. customThe solvent was removed by evaporation

出典と根拠

ORDレコード
ord-f9ee56fe44e8463f876ea478c339747b
出典データセット
uspto-grants-1988_05
特許番号
US04745113

関連ノート

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