Water → 1-Hexanoyl 2-amino benzimidazole

HRID 1252697

反応式

HRID 1252697 の反応式
[NH2:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.C(N(CC)CC)C.[C:18](Cl)(=[O:24])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23].O>CC(C)=O>[C:18]([N:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=[C:2]1[NH2:1])(=[O:24])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]

参加物

6

反応物 4

HCID 962Water2 回HCID 8471TriethylamineHCID 136242-AminobenzimidazoleHCID 67340Hexanoyl chloride

生成物 1

HCID 139581201-Hexanoyl 2-amino benzimidazole収率 50.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

A solution of 2-amino benzimidazole (8 g, or 0.060 mole) and triethylamine (10 g, or 0,099 mole) in 150 ml of anhydrous acetone, is chilled to a temperature of -65° C. under nitrogen. To this solution is added 12.1 g (0.09 mole) hexanoyl chloride in solution in 150 ml of anhydrous acetone at a temperature of -60° C. After the mixture has been agitated at this temperature for around 1 hour, 100 ml of water is added to it, at a temperature of between -30° and -20° C., after which it is all poured into 500 ml of water. The precipitate is filtered, and dried in a dessicator. After purification, 7 g (50.5% yield) is obtained of a crystallized compound having a melting point of 200° C. and the following structure (90% purity): ##STR5##

後処理

  1. filtrationThe precipitate is filtered
  2. customdried in a dessicator
  3. customAfter purification
  4. custom7 g (50.5% yield) is obtained of a crystallized compound

出典と根拠

ORDレコード
ord-0d200a90f3a54d6e8d428bc311d700dc
出典データセット
uspto-grants-1988_05
特許番号
US04745125

関連ノート

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