N-(3-benzoylthiopropanoyl)-L-alanine → N-(3-Sulfanylpropanoyl)-L-alanine
反応式
C([S:9][CH2:10][CH2:11][C:12]([NH:14][C@H:15]([C:17]([OH:19])=[O:18])[CH3:16])=[O:13])(=O)C1C=CC=CC=1>O.[OH-].[NH4+]>[SH:9][CH2:10][CH2:11][C:12]([NH:14][C@H:15]([C:17]([OH:19])=[O:18])[CH3:16])=[O:13]参加物
4
実験手順
N-(3-benzoylthiopropanoyl)-L-alanine (4.2 g) is dissolved in a mixture of water (7.5 ml) and concentrated ammonium hydroxide (6 ml). After one hour, the mixture is diluted with water, filtered and the filtrate is extracted with ethyl acetate. The aqueous phase is acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic phase is washed with water, dried and concentrated to dryness in vacuo. The residue is crystallized from ethyl acetate-hexane to yield 1.87 g of N-(3-mercaptopropanoyl)-L-alanine, m.p. 79°-81°.
後処理
- filtrationfiltered
- extractionthe filtrate is extracted with ethyl acetate
- extractionextracted with ethyl acetate
- washThe organic phase is washed with water
- customdried
- concentrationconcentrated to dryness in vacuo
- customThe residue is crystallized from ethyl acetate-hexane
出典と根拠
- ORDレコード
- ord-9116ed926520467993fe44e21630607f
- 出典データセット
- uspto-grants-1988_05
- 特許番号
- US04745124
反応ノート
読み込み中…