Ammonia → 1-[2-carbamoylmethyl-3-mercaptopropanoyl]-L-proline
反応式
[SH:1][CH2:2][CH:3]([CH2:14][C:15]([O:17]C)=O)[C:4]([N:6]1[CH2:13][CH2:12][CH2:11][C@H:7]1[C:8]([OH:10])=[O:9])=[O:5].[NH3:19]>O>[C:15]([CH2:14][CH:3]([CH2:2][SH:1])[C:4]([N:6]1[CH2:13][CH2:12][CH2:11][C@H:7]1[C:8]([OH:10])=[O:9])=[O:5])(=[O:17])[NH2:19]参加物
4
実験手順
2.1 g of the product from Example 62, Step (d) is dissolved in a mixture of water (40 ml) and concentrated ammonia (40 ml). After one hour the reaction mixture is concentrated in 1/3 volume, and applied to a column of Dowex 50 resin in the hydrogen cycle. The product is eluted with water. The aqueous is extracted with ethyl acetate and then concentrated to dryness to yield 1.4 g of the named product, Rf =0.50 (silica gel-chloroform:methanol:acetic acid:water).
後処理
- concentrationAfter one hour the reaction mixture is concentrated in 1/3 volume
- washThe product is eluted with water
- extractionThe aqueous is extracted with ethyl acetate
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-9e0fa69636da40f8b8d84f2aea6a78ef
- 出典データセット
- uspto-grants-1988_05
- 特許番号
- US04745124
反応ノート
読み込み中…