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Dicyclohexylcarbodiimide → HCID 54399293、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | 2-(Dimethoxyphosphoryl)acetic acid | HCID 189964 | — |
| 反応物 | Methyl 4-aminopyridine-2-carboxylate | HCID 3759117 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 54399293 | HCID 54399293 | — |
反応手順
A mixture of 1.0 g of methyl 4-aminopicolinate, 1.0 g of α-(dimethylphosphono)-acetic acid and 1.0 g of dicyclohexylcarbodiimide in 10 ml of methylene chloride is stirred at room temperature for 6 hours. After filtration and removal of solvent the residue is chromatographed on silica gel with 5% methanol/methylene chloride as the eluent to afford methyl 4-(α-dimethylphosphonoacetamido)-picolinate as a viscous oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04746653 |
| 出典データセット | uspto-grants-1988_05 |
| ORD ID | ord-a2a22c313bd44465a2801eae875476c0 |
| 出典メモ | uspto-grants-1988_05 |