Carbon Tetrachloride → 1-(p-Chlorophenoxy)-3,3-dimethyl-4-chloro-2-butanone

HRID 1253038

反応式

HRID 1253038 の反応式
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][CH2:7][C:8](=[O:14])[C:9]([CH3:13])([CH3:12])[CH2:10]O)=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Cl)(Cl)(Cl)[Cl:37]>>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][CH2:7][C:8](=[O:14])[C:9]([CH3:13])([CH3:12])[CH2:10][Cl:37])=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 5943Carbon TetrachlorideHCID 11776TriphenylphosphineHCID 201382891-(p-Chlorophenoxy)-3,3-dimethyl-4-hydroxy-2-butanone

生成物 1

HCID 201382951-(p-Chlorophenoxy)-3,3-dimethyl-4-chloro-2-butanone

実験手順

Into a 100-ml egg plant type flask were placed 2.4 g of 1-(p-chlorophenoxy)-3,3-dimethyl-4-hydroxy-2-butanone, 2.6 g of triphenylphosphine and 50 ml of carbon tetrachloride, which were then refluxed for 18 hours. The reaction mixture was cooled, the crystals separating out were filtered off, and the filtrate was concentrated in a vacuum. The residue obtained was purified by silica gel column chromatography, giving 1.8 g of the above-identified desired compound.

後処理

  1. customInto a 100-ml egg plant type flask were placed
  2. temperatureThe reaction mixture was cooled
  3. customthe crystals separating out
  4. filtrationwere filtered off
  5. concentrationthe filtrate was concentrated in a vacuum
  6. customThe residue obtained
  7. customwas purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-f8e4ddd6dd9644e38fd966178d844820
出典データセット
uspto-grants-1988_05
特許番号
US04746673

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