Formic Acid → 1-Chloro-3,3,4-trimethylpentan-2-one

HRID 1253128ノート

反応式

HRID 1253128 の反応式
[Cl:1][CH:2]=[C:3]([O:10]C1C=CC=CC=1)[C:4]([CH3:9])([CH3:8])[CH:5]([CH3:7])[CH3:6].C(O)=O.Cl>C(Cl)Cl>[Cl:1][CH2:2][C:3](=[O:10])[C:4]([CH3:9])([CH3:8])[CH:5]([CH3:7])[CH3:6]

参加物

5

反応物 3

HCID 284Formic AcidHCID 313Hydrochloric AcidHCID 54514707[(1-Chloro-3,3,4-trimethylpent-1-en-2-yl)oxy]benzene

生成物 1

HCID 132952261-Chloro-3,3,4-trimethylpentan-2-one収率 77%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

238 g (1 mol) of 1-chloro-2-phenoxy-3,3,4-trimethyl-pent-1-ene are stirred with 500 g of formic acid and 50 g of concentrated hydrochloric acid for 2 hours at 80° C. The mixture is diluted with methylene chloride, and is washed once with water and four times with dilute sodium hydroxide solution. After the mixture has been dried over sodium sulphate, the solvent is stripped off in vacuo, and the residue is distilled over a column. 125 to 135 g (77-83% of theory) of 1-chloro-3,3,4-trimethyl-pentan-2-one of boiling point 88°-93° C./16 mbar are obtained. ##STR17##

後処理

  1. washis washed once with water and four times with dilute sodium hydroxide solution
  2. dry with materialAfter the mixture has been dried over sodium sulphate
  3. distillationthe residue is distilled over a column

出典と根拠

ORDレコード
ord-d9f745b993ab404499128767c593ba12
出典データセット
uspto-grants-1988_05
特許番号
US04747869

反応ノート

読み込み中…