Methanol → 5-(2-Amino-1,3-benzothiazol-6-yl)imidazolidine-2,4-dione

HRID 1253199ノート

反応式

HRID 1253199 の反応式
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH:11]=O)[CH:8]=[CH:7][C:5]=2[N:6]=1.[C:13](=[O:16])([O-])[O-].[NH4+:17].[NH4+:18].[C-]#N.[Na+].[CH3:22][OH:23]>O>[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH:11]3[NH:18][C:22](=[O:23])[NH:17][C:13]3=[O:16])[CH:8]=[CH:7][C:5]=2[N:6]=1

参加物

6

反応物 4

HCID 887MethanolHCID 8929Sodium CyanideHCID 517111Ammonium CarbonateHCID 138215412-Aminobenzo[d]thiazole-6-carbaldehyde

生成物 1

HCID 138215425-(2-Amino-1,3-benzothiazol-6-yl)imidazolidine-2,4-dione

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

22.5 g (0.126 mol) of 1b, dissolved in 400 ml of methanol, are added dropwise to a solution of 50.9 g (0.531 mol) of ammonium carbonate and 9.6 g (0.196 mol) of sodium cyanide in 400 ml of water, and the mixture is stirred at 60° C. for 20 hours. After the methanol has been removed by distillation in vacuo, the remaining solution is acidified, at 0° C., to pH 2 with 2N HCl, then the pH is returned to 4 with 2N sodium hydroxide solution, and the precipitated product is filtered off with suction.

後処理

  1. customAfter the methanol has been removed by distillation in vacuo
  2. customis acidified, at 0° C., to pH 2 with 2N HCl
  3. filtrationthe precipitated product is filtered off with suction

出典と根拠

ORDレコード
ord-eba47dc4d34d4ca8a5a74e82c5283915
出典データセット
uspto-grants-1988_05
特許番号
US04748163

反応ノート

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