Acetic Anhydride → 2-Methyl-[1,3]thiazolo[4,5-c]pyridine

HRID 1253220ノート

反応式

HRID 1253220 の反応式
[N+:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[SH:10])([O-])=O.[C:11](OC(=O)C)(=O)[CH3:12]>C(O)(=O)C.[Zn]>[CH3:11][C:12]1[S:10][C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:1]=1

参加物

5

反応物 2

HCID 7918Acetic AnhydrideHCID 178526807HCID 178526807、化合物

生成物 1

HCID 6407212-Methyl-[1,3]thiazolo[4,5-c]pyridine収率 44.5%

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 176Acetic Acid溶媒

実験手順

A mixture of 1.3 g of 3-nitropyridine-4-thiol in 4 ml of acetic acid and 15 ml of acetic anhydride containing 1.5 g of zinc dust was heated at reflux for four hours. The reaction mixture was cooled and concentrated to an oil. The oil was dissolved in 5N sodium hydroxide and the alkaline solution was extracted with diethyl ether. The extracts were combined, dried and concentrated to dryness to afford 557 mg of 2-methylthiazolo[4,5-c]pyridine. M+Theory 150; Found 150.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for four hours
  3. temperatureThe reaction mixture was cooled
  4. concentrationconcentrated to an oil
  5. dissolutionThe oil was dissolved in 5N sodium hydroxide
  6. extractionthe alkaline solution was extracted with diethyl ether
  7. customdried
  8. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-b2b877af11624f7986d13499d71bdd0c
出典データセット
uspto-grants-1988_05
特許番号
US04748172

反応ノート

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