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Sodium Iodide → HCID 15671927、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | 1-Azabicyclo[2.2.2]octane-4-carboxamide | HCID 10130069 | — |
| 反応物 | (4-Methoxyphenyl)methyl (6R,7R)-3-(chloromethyl)-8-oxo-7-((2-phenylacetyl)amino)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate | HCID 10874591 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | HCID 15671927 | HCID 15671927 | 33.9% |
反応手順
p-Methoxybenzyl 7β-phenylacetamido-3-chloromethyl-3-cephem-4-carboxylate (980 mg) was suspended in acetone (20 ml), and sodium iodide (362 mg) was added to the suspension and stirred at room temperature for 1 hour. To the resulting suspension was added 4-carbamoylquinuclidine (313 mg) under ice-cooled condition, and the mixture was stirred for 2 hours. The reaction mixture was filtered, and diethyl ether (70 ml) was added to the filtrate. The deposited solid was filtered to obtain the desired product (500 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04748171 |
| 出典データセット | uspto-grants-1988_05 |
| ORD ID | ord-2adfb7a2894947a6ac8716409d2b2423 |
| 出典メモ | uspto-grants-1988_05 |