HCID 178471941、化合物 → Ethyl 4-hydroxy-3,4-dihydro-1,5-naphthyridine-3-carboxylate
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](/[N:7]=[CH:8]/[CH:9]([C:15]([O:17]CC)=O)[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:2]=1>O(C1C=CC=CC=1)C1C=CC=CC=1>[OH:17][CH:15]1[C:2]2[C:3](=[CH:4][CH:5]=[CH:6][N:1]=2)[N:7]=[CH:8][CH:9]1[C:10]([O:12][CH2:13][CH3:14])=[O:11]参加物
3
反応条件
- 温度
- 250 °C
実験手順
Diethyl [(E)-(pyridin-3-ylimino)methyl]malonate (9 g, 34 mmol) was dissolved in 1,1′-oxydibenzene (150 ml). The mixture was heated at 250° C. for 2 hours, and then cooled to room temperature. The reaction mixture was filtered to give ethyl 4-hydroxy-3,4-dihydro-1,5-naphthyridine-3-carboxylate.
後処理
- temperaturecooled to room temperature
- filtrationThe reaction mixture was filtered
出典と根拠
- ORDレコード
- ord-c8cab84f26644dd2b6cbc67822f071e7
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08455477B2
反応ノート
読み込み中…