Potassium Hydroxide → N-(6-(2,8-Diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)-2-chlorobenzamide

HRID 1253752ノート

反応式

HRID 1253752 の反応式
[OH-].[K+].[Cl:3][C:4]1[CH:39]=[CH:38][CH:37]=[CH:36][C:5]=1[C:6]([NH:8][CH:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:18]([N:20]3[CH2:24][CH2:23][C:22]4([CH2:29][CH2:28][N:27](C(=O)C(F)(F)F)[CH2:26][CH2:25]4)[CH2:21]3)=[O:19])[CH:16]=2)[CH2:11][CH2:10]1)=[O:7]>CO>[CH2:21]1[C:22]2([CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:23][CH2:24][N:20]1[C:18]([C:15]1[CH:16]=[C:17]2[C:12]([CH2:11][CH2:10][CH:9]2[NH:8][C:6](=[O:7])[C:5]2[CH:36]=[CH:37][CH:38]=[CH:39][C:4]=2[Cl:3])=[CH:13][CH:14]=1)=[O:19]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 595057192-Chloro-N-(6-(8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)benzamide

生成物 1

HCID 59505509N-(6-(2,8-Diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)-2-chlorobenzamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2 M KOH solution (4 ml) was added to a stirred solution of 2-chloro-N-(6-(8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)benzamide (200 mg, 0.374 mmol, 1 eq.) in MeOH (4 ml) and the mixture was stirred for 5 h. Methanol was removed under reduced pressure and it was diluted with EtOAc (100 ml) and washed with water (10 ml) and brine (20 ml). The organic layer was dried over sodium sulfate, filtered and concentrated to dryness. The crude material was used for the next step without further purification.

後処理

  1. customMethanol was removed under reduced pressure and it
  2. additionwas diluted with EtOAc (100 ml)
  3. washwashed with water (10 ml) and brine (20 ml)
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated to dryness
  7. customThe crude material was used for the next step without further purification

出典と根拠

ORDレコード
ord-ae36efb8cde9449898537cc8f0716fb2
出典データセット
uspto-grants-2013_06
特許番号
US08455475B2

反応ノート

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