Hydrogen Peroxide → 5-amino-1-cyclopentyl-1H-pyrazole-4-carboxamide

HRID 1253792

反応式

HRID 1253792 の反応式
[OH:1]O.[NH2:3][C:4]1[N:8]([CH:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)[N:7]=[CH:6][C:5]=1[C:14]#[N:15]>C(O)C.N>[NH2:3][C:4]1[N:8]([CH:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)[N:7]=[CH:6][C:5]=1[C:14]([NH2:15])=[O:1]

参加物

5

反応物 2

HCID 784Hydrogen PeroxideHCID 179603715-Amino-1-cyclopentyl-1H-pyrazole-4-carbonitrile

生成物 1

HCID 117011915-amino-1-cyclopentyl-1H-pyrazole-4-carboxamide

試薬・触媒・溶媒 2

HCID 222Ammonia溶媒HCID 702Ethanol溶媒

実験手順

85 ml of 30% strength hydrogen peroxide solution are added to a solution of 5-amino-1-cyclopentyl-1H-pyrazole-4-carbonitrile (6.74 g, 38.3 mmol) in a mixture of 300 ml of ethanol and 371 ml of concentrated aqueous ammonia solution at room temperature and stirred at room temperature overnight. The nonaqueous solvents are then stripped off in a rotary evaporator. The product precipitates as solid from the remaining mixture and is filtered off with suction, washed with diethyl ether and dried under high vacuum.

後処理

  1. customThe nonaqueous solvents are then stripped off in a rotary evaporator
  2. customThe product precipitates as solid from the remaining mixture
  3. filtrationis filtered off with suction
  4. washwashed with diethyl ether
  5. customdried under high vacuum

出典と根拠

ORDレコード
ord-2c25040e8f5148d7bd8dac74c9d9ebc7
出典データセット
uspto-grants-2013_06
特許番号
US08455502B2

関連ノート

読み込み中…