Methanol → HCID 58478790、化合物
反応式
[CH3:1][O:2][CH:3]=[CH:4][C:5]1[N:10]=[C:9]2[CH2:11][O:12][C:13](=[O:14])[C:8]2=[CH:7][CH:6]=1.[CH3:15][OH:16]>S(=O)(=O)(O)O>[CH3:1][O:2][CH:3]([O:16][CH3:15])[CH2:4][C:5]1[N:10]=[C:9]2[CH2:11][O:12][C:13](=[O:14])[C:8]2=[CH:7][CH:6]=1参加物
4
反応条件
- 温度
- 70 °C
実験手順
To a solution of 2-(2-methoxy-vinyl)-7H-furo[3,4-b]pyridin-5-one (108 mg, 0.57 mmol) in anhydrous MeOH (10 mL) is added three drops of concentrated sulfuric acid. The reaction solution is stirred and heated at 70° C. for 18 h at which time the starting material is consumed. The reaction mixture is then diluted with EtOAc (100 mL), and then washed with saturated aqueous NaHCO3 (2×75 mL). The organic solution is dried (Na2SO4) and concentrated to give the title compound as a brown oil (104 mg, 83%).
後処理
- customis consumed
- additionThe reaction mixture is then diluted with EtOAc (100 mL)
- washwashed with saturated aqueous NaHCO3 (2×75 mL)
- dry with materialThe organic solution is dried (Na2SO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-7419df76497d48309d6d03d56786177a
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08455535B2
反応ノート
読み込み中…